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KMID : 0613820110210091259
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Journal of Life Science
2011 Volume.21 No. 9 p.1259 ~ p.1265
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Fiber Type Specific Expression of Toll-like Receptor4, IL-6, TNF-α, and Suppressor of Cytokine Signaling-3 after Acute Exercise in Rat Skeletal Muscles
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Lee Won-Jun
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Abstract
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The purpose of this study was to determine whether a single bout of aerobic exercise affects the expression level of toll-like receptor4 (TLR4), IL-6, TNF-α, and suppressor of cytokine signaling-3 (SOCS-3) expression in rat hindlimb muscles depending on fiber types. To accomplish this, thirteen 7-wk Balb/c male mice were randomly assigned to an experimental group or a control group. The exercise protocol consisted of a single bout of treadmill exercise (inclination 10℃, speed 17 cm/sec 10 min, 33 cm/sec 10 min, 50 cm/sec) and the animals were killed 24 hr after the exhaustion protocol. The level of TLR4, IL-6, TNF-α, and SOCS-3 mRNA expression was measured by quantitative real-time PCR in soleus and plantaris muscles. A single bout of aerobic treadmill exercise increased TLR4 mRNA expression in the soleus muscle (p<0.05), whereas plantaris TLR4 mRNA expression did not change. Additionally, acute exercise led to a significant increase in IL-6, TNF-α, and SOCS-33 mRNA in the soleus muscle, while transcripts of these genes were not affected by exercise in the plantaris muscle. In conclusion, expression level of several immune-related genes such as TLR4, cytokines, and SOCS-3 is regulated by acute exercise in a fiber type specific manner.
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KEYWORD
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Acute exercise, toll-like receptor4 (TLR4), cytokines, suppressor of cytokine signaling-3(SOCS-3), skeletal muscle fiber type
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